多种营养物质降低了ADHD儿童的氧化压力:随机对照试验数据的调解/适度分析
Lisa M Robinette1, Irene E Hatsu1,2, Olorunfemi Adetona3
1Department of Human Sciences, The Ohio State University, Columbus, OH, USA.
Journal of attention disorders
|August 7, 2025
概括
在儿童中治疗ADHD的多营养补充剂在八周内降低了氧化应激标志物,特别是活性氧代谢物 (ROM). 这表明在ADHD中营养摄入量和减少氧化应激之间存在潜在的联系,需要进一步调查.
科学领域:
- 营养精神病学 营养精神病学
- 生物化学 生物化学
- 儿科神经学 儿科神经学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 与氧化压力 (OS) 有关,可能是由于营养缺乏.
- 之前的试验表明,多营养补充剂可以改善ADHD症状.
- 多种营养素对ADHD中抗氧化剂状况和正常运作的影响仍然不清楚.
研究的目的:
- 为了比较抗氧化剂 (AO) 和OS生物标志物的变化8周多营养补充剂后与ADHD儿童的安慰剂相比.
- 评估基线AO/OS生物标志物及其变化是否适度或中度治疗反应.
主要方法:
- 从青少年ADHD的微量营养素 (MADDY) RCT中分析血样本.
- 在基线和8周测量谷氨过氧化酶 (GPx),谷氨减少酶 (GR),氧化应激指数 (OSI),活性氧代谢物 (ROM) 和生物抗氧化潜力 (BAP).
- 使用t测试/曼-惠特尼U测试和逻辑回归进行统计比较,用于调度/适度分析.
主要成果:
- 分析了77名儿童 (9.9±1.7岁,71%男性).
- 在8周后,与安慰剂相比,多营养治疗显著降低了ROM (p=0.017).
- 两组之间在OSI,BAP,GPx或GR中没有发现显著差异;基线生物标志物没有缓解反应,OSI/ROM的变化显示出对调解的无意义趋势.
结论:
- 八周的多营养补充剂减少了ADHD儿童的ROM,表明氧化应激的潜在减少.
- 虽然抗氧化剂状况没有显著变化,但初步发现表明减少OS和症状改善之间存在联系,这值得进一步研究ADHD病变发生过程中的OS.
关键词:
更多关于 ADHD ADHD 的文章有关RCT的RCT是什么抗氧化剂是一种抗氧化剂.孩子们的孩子们的孩子们的孩子们.葡萄糖氨酸氨酸是什么?多种营养成分的多种营养成分.氧化应激是一种氧化应激.补充补充补充补充补充补充更多相关视频
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