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液体活检 - 一个叙述性审查,更新了当前针对免疫治疗的美国政府临床试验

Fan Shen¹, Samar A Zailaie², Brian Chiu¹

¹Department of Laboratory Medicine, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.

Future science OA

|August 7, 2025

概括

液体活检通过分析体液中的瘤标记物来提供先进的癌症检测和监测. 本综述分析了当前的技术及其在精准医学和治疗耐药性识别中的作用.

科学领域:

在瘤学瘤学.
生物化学生物化学
基因组学就是基因组学.

背景情况:

液体活检分析来自瘤的成分,如循环瘤细胞 (CTC),循环瘤DNA (ctDNA) 和患者生物流体中的细胞外囊泡 (EV).
了解瘤异质性,基因突变和克隆进化对于有效的癌症管理至关重要.

研究的目的:

提供当前液体活检技术的全面国际分析.
评估液体活检在隔离瘤标志物的作用,用于癌症检测,预测和治疗监测.

主要方法:

在PubMed/Medline,Scopus和Cochrane数据库中使用范围审查模型进行叙事审查.
搜索了过去五年 (2023年6月 - 2024年10月) 发表的关于液体活检的文章,重点是评论文章.
包括美国注册的免疫疗法和液体活检临床试验的综述 (更新于2025年3月).

主要成果:

从数据库中选了2645篇文章和从灰色文献中选了45篇文章,检索了325篇文章的全文.
确定液体活检作为隔离CTC,ctDNA和瘤EVs的方法.
发现了25项美国注册的免疫疗法和液体活检临床试验,其中20项正在招募,5项尚未招募.

结论:

液体活检为癌症检测,监测和个性化治疗提供了新的机会.
这些技术有助于识别治疗耐药性的标志物,并了解瘤进展.
液体活检分析的进步提高了瘤学的精准医学方法.

关键词:

液体活检液体活检这是一个RNARNARNARNARNA.癌症癌症癌症癌症癌症在循环中的瘤DNA.循环中的瘤细胞.精准医学是一门精准医学.蛋白质组学是什么意思瘤的细胞外囊泡.

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