慢性背痛与老年人认知衰退之间的纵向关联与调解分析:对四个基于人口的数据库进行分析
Frank F Huang1, Yuying Zhang2, Lian Liu3
1Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.
European journal of pain (London, England)
|August 7, 2025
概括
老年人的慢性背痛 (CBP) 增加了认知能力下降和与记忆有关的疾病的风险. 吸烟,体力活动和睡眠等生活方式因素显著影响这种风险,突出了针对性干预的必要性.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 慢性背痛 (CBP) 在老年人中越来越令人担忧.
- 以前的研究表明,CBP与加速认知衰退之间存在潜在联系.
- 有限的跨国研究存在于CBP对认知的影响和生活方式因素的作用.
研究的目的:
- 在一个跨国队列中调查CBP和认知衰退之间的关联.
- 检查可修改的生活方式因素对这种关系的影响.
- 为了告知公共卫生战略,以减轻CBP的老年人认知障碍.
主要方法:
- 分析了来自17个国家的18558个人 (2010-2023) 的数据.
- 利用线性混合效应模型和调解分析 (结构方程建模).
- 评估了CBP和与记忆相关的疾病,认知表现指标和主观认知衰退之间的关联,并调整了混因素.
主要成果:
- 在美国和欧洲,CBP与记忆相关疾病和主观认知衰退的风险增加有关.
- 聚合分析证实了CBP和认知衰退指标之间的重要,尽管很弱的关联.
- 酒精摄入加剧了认知衰退,而戒烟,体力活动和充足的睡眠 (7-9小时) 减轻了风险.
结论:
- 在老年人中,CBP增加了加速认知衰退的风险.
- 可修改的生活方式因素在调节这种风险方面发挥着至关重要的作用.
- 对于患有CBP的老年人,建议进行认知监测和专注于戒烟,身体活动和睡眠优化的定制干预措施.
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