Tribulus terrestris L. 提取物通过抑制TNF-α介导的巨细胞炎症来缓解动脉样硬化
Zheng Yu-Qian1,2, Yang Lian2, Zhang Xiang2
1School of Medicine, Jinhua University of Vocational Technology, Jinhua, China.
概括
三土草L. (Baijili) 通过减少炎症,减轻小鼠的动脉样硬化. 它的成分Tigogenin抑制了巨细胞的关键炎症途径,这表明它有可能治疗心血管疾病.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学 是一个学科.
- 传统中国医药 传统中国医药
背景情况:
- 动脉样硬化 (AS) 是导致心血管疾病的主要原因之一.
- 在传统医学中,Tribulus terrestris L. (Baijili,BJL) 已证明具有抗炎和心血管益处.
- 以前的研究表明,BJL抑制了巨细胞中的炎症因素,但直接的抗动脉样硬化作用需要确认.
研究的目的:
- 在小鼠模型中研究BJL的抗动脉样硬化作用.
- 确定BJL作用的关键基因和分子机制.
- 评估BJL的组分,Hecogenin (Heco) 和Tigogenin (Tigo) 在AS中的作用.
主要方法:
- 在使用高脂肪饮食 (HFD) 的ApoE-/-小鼠中诱导动脉样硬化,然后用BJL或Lipitor治疗.
- 生物信息学,WGCNA和机器学习确定了与巨相关的AS关键功能基因 (ASKFGs).
- 分子对接,动力学模拟,RT-qPCR和西部斑点分析了分子相互作用和炎症基因/蛋白质表达.
主要成果:
- 在HFD养的ApoE-/-小鼠中,BJL治疗显著减少了大动脉斑块面积,血清TC,LDL-C和炎症性细胞因子.
- 确定的主要AS目标包括TNF,MMP-9,CXCR2和CD36.
- 提戈 (Tigo) 显示出强烈的结合TNF-α和MMP-9,抑制了巨细胞中LPS诱导的炎症标志物,并抑制了TNF-α/NF-κB通路.
结论:
- BJL通过抑制巨细胞介导的炎症,部分通过CD36和CXCR2降低调节来缓解ApoE-/-小鼠的动脉样硬化.
- 提戈宁是BJL中的一个关键的氨酸,通过抑制TNF-α的产生和NF-κB信号通路,有助于抗动脉样硬化作用.
- 提戈根因作为一种治疗药物,有望向动脉样硬化的炎症机制.
关键词:
三草L.L.L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris L.Tribulus terrestris.Tribulus terrestris.L.Tribulus terrestris.L.Tribulus terrestris.动脉样硬化 动脉样硬化巨细胞是什么?巨细胞是什么?分子动力学分子动力学这就是Tigogenin.更多相关视频
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