咖啡摄入量对膀癌风险的遗传影响:双样本孟德尔随机化分析
Qi Zeng1,2, Yu Cheng3,4, Chenlong Wang5
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, 330008, Nanchang, China. zhengguanghao63@163.com.
Food & function
|August 7, 2025
概括
基因预测咖啡摄入量与膀癌 (BLCA) 的风险增加有关. 这项研究表明,咖啡消费可能是BLCA的独立风险因素,需要进一步调查.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 膀癌 (BLCA) 由于发病率和成本的增加,构成了重大的公共卫生挑战.
- 现有的BLCA风险因素知识,如遗传和环境是不完整的.
- 咖啡消费与BLCA风险之间的关联尚未得到充分理解.
研究的目的:
- 研究基因预测咖啡摄入量与膀癌风险之间的潜在因果关系.
- 为了确定咖啡摄入量是否是BLCA的独立风险因素,调整吸烟.
- 通过先进的分析方法探索潜在的机制.
主要方法:
- 使用单变量门德尔随机化 (UVMR) 来评估咖啡与BLCA的关联.
- 采用多变量门德尔随机化 (MVMR) 来调整吸烟状态.
- 进行了两步MR和生物信息学分析,以探索潜在的机制.
主要成果:
- 紫外线MR表明,基因预测的咖啡摄入量与BLCA风险之间存在显著的正相关性 (OR = 2.074,P = 0.046).
- 在调整吸烟后,MVMR证实了咖啡摄入量和BLCA风险之间的显著正相关性 (OR = 2.019,P = 0.037).
- 研究结果表明,咖啡摄入可能是BLCA的独立风险因素.
结论:
- 遗传证据支持咖啡消费与膀癌风险增加之间的潜在联系.
- 咖啡摄入量可能代表BLCA的独立风险因素.
- 建议适度饮用咖啡,并建议对机制进行进一步的研究.
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