在退伍军人卫生管理局阿尔法-1抗素缺乏症的流行病学
Leonard Riley1, Robert Fredenrich2, Matthew Bearce2
1Kansas City VA Medical Center, Pulmonary, Critical Care, and Sleep Medicine, Kansas City, Missouri, United States; elmer.riley2@va.gov.
Annals of the American Thoracic Society
|August 7, 2025
概括
阿尔法-1抗素缺乏症 (AATD) 在美国退伍军人中很普遍,影响了COPD和肝脏疾病患者. 由于查率较低,增加测试和意识至关重要.
科学领域:
- 肺部医学 肺部医学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 阿尔法-1抗素缺乏症 (AATD) 是慢性阻塞性肺病 (COPD) 和肝病的未被认可的遗传原因.
- 美国退伍军人中AATD的流行病学和负担在很大程度上是未知的.
研究的目的:
- 在退伍军人卫生管理局 (VHA) 调查AATD和严重AATD的特征和流行病学.
主要方法:
- 利用2010年1月1日至2019年12月31日的电子健康记录,用于人口统计,临床和测试数据.
- 根据血清AAT水平和特定基因型,定义了中度和严重的AATD.
- 采用多变量逻辑回归来确定与AATD检测相关的因素.
主要成果:
- 在1200万退伍军人中,有175,508人接受了测试,其中8,832人被诊断为中级AATD,3,088人患有严重AATD.
- AATD阳性率在每1000名测试人群中为62-76人.
- 在COPD (4.04%) 和肝病 (17.91%) 的退伍军人中观察到较低的测试率.
- 年龄较小,白人种族,没有吸烟史与AATD检测有关.
结论:
- 证实AATD在美国的流行程度很高. 退伍军人人口. 老兵人口.
- 低的测试率表明需要在符合条件的退伍军人中提高AATD意识.
- 这项国家分析突出显示,在VHA中,AATD查和诊断存在重大差距.
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