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纤维细胞激活蛋白向PET/CT使用[18 F]FAP-2286评估肺癌:与[18 F]FDG PET/CT进行比较研究

Yu Ma¹, Guanghui Liu¹, Bulin Du¹

¹Department of Nuclear Medicine, The First Hospital of China Medical University, 155 Nanjing St, Shenyang, 110001, Liaoning, China.

European journal of nuclear medicine and molecular imaging

|August 7, 2025

概括

新的[18F]FAP-2286 PET/CT成像显示,与[18F]FDG PET/CT相比,在肺癌患者中改善了骨转移的检测和更准确的分期. 这种新型的追踪器为全面的肺癌评估提供了有价值的替代方案.

科学领域:

核医学是一种核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

纤维细胞激活蛋白 (FAP) 是癌症成像的目标.
[18F]FAP-2286是一种具有增强稳定性和选择性的新型循环标记剂.
在肺癌中[18F]FAP-2286 PET/CT的诊断实用性需要进一步研究.

研究的目的:

为了比较[18F]FAP-2286 PET/CT与[18F]FDG PET/CT用于肺癌分期的诊断性能.
评估[18F]FAP-2286在检测初级瘤,淋巴结和远程转移中的有效性.
评估SUVmax和TBR等数量参数,用于两个标记器.

主要方法:

怀疑患有肺癌的30名患者接受了[18F]FAP-2286和[18F]FDG PET/CT.
组织病理学和临床随访作为参考标准.
定量分析包括SUVmax和目标与背景比率 (TBR).

主要成果:

[18F]FAP-2286 PET/CT在原发性瘤中显著增加了TBR (P < 0.001),但在SUVmax中没有显著差异.
[18F]FAP-2286 PET/CT表明转移性淋巴结的检测率较低,但真实阳性率更高.
[18F]FAP-2286 PET/CT 显示出对骨 (98.80%vs. 72.46%) 和大脑转移 (100%vs. 72.73%) 的检测优异.

结论:

与[18F]FDG PET/CT相比,FAP-2286 PET/CT在检测骨转移方面提供了更高的性能.
这种追踪器为肺癌提供了更准确的N和M分期.
[18F]FAP-2286 PET/CT可能是全面评估肺癌患者的有价值的替代方案.

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