在社区的老年人中,MIND饮食和海马硬化症
Puja Agarwal1,2, Sonal Agrawal3, Maude Wagner4
1Rush Alzheimer Disease Center, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
JAMA network open
|August 7, 2025
概括
坚持地中海饮食方法来阻止高血压干预神经退行性延迟 (MIND) 饮食与降低海马硬化症 (HS) 和晚期NC的HS的几率有关. 这种饮食模式可以保护大脑健康,降低痴呆风险.
科学领域:
- 神经病理学神经病理学
- 营养神经科学 营养神经科学
- 老年医学 老年医学
背景情况:
- 海马硬化 (HS) 是痴呆的一个关键病理,包括阿尔茨海默病和LATE-NC.
- 饮食在HS和LATE-NC发展中的作用尚不清楚.
- 调查MIND饮食等饮食模式可能为痴呆症预防提供见解.
研究的目的:
- 检查MIND饮食与HS和HS与LATE-NC的存在之间的关联.
- 探索MIND饮食坚持和海马神经元损失严重程度之间的关系.
主要方法:
- 来自Rush记忆和衰老项目的809名解剖参与者的队列研究.
- 饮食数据每年收集长达18年,使用食物频率问卷计算MIND饮食分数.
- 神经病理学评估包括HS (血素和欧染色) 和LATE-NC (TDP-43免疫组织化学);海马神经元损失被半定量得分.
主要成果:
- 较高的MIND饮食得分与较低的HS (OR,0.78) 和HS与LATE-NC (OR,0.79) 的几率有关.
- MIND饮食与较不严重的海马神经元损失有显著的关联 (趋势P=0.01).
- 坚持MIND饮食与降低痴呆风险有关,部分通过HS进行调解.
结论:
- 坚持MIND饮食与HS的可能性降低,HS与LATE-NC,以及海马神经元损失有关.
- 这种MIND饮食可能在防止导致痴呆的神经退行性变化方面起到保护作用.
- 这些发现强调了饮食干预在促进大脑健康和减轻痴呆症方面的潜力.
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