作为心脏衰竭的危险因素,左捆支部块是心脏衰竭的危险因素
Anna-Sophie Thein1,2, Shalini Dixit1, Elsayed Z Soliman3
1Division of Cardiology, Department of Medicine, University of California, San Francisco.
JAMA network open
|August 7, 2025
概括
左捆支部阻塞 (LBBB) 在正常心脏结构的个体中显著增加患心力衰竭 (HF) 和左心室喷射率 (LVEF) 降低的风险. 针对LBBB的早期干预可以防止HF的进展.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 预防医学 预防医学
背景情况:
- 左捆支部阻塞 (LBBB) 是心力衰竭 (HF) 的已知危险因素.
- 在结构正常的心脏和保存左心室喷射分数 (LVEF) 的个体中,LBBB和HF风险之间的关联仍未得到充分研究.
研究的目的:
- 调查LBBB与社区居住的正常心脏结构的老年人发生高血压风险之间的关联.
主要方法:
- 一项使用心血管健康研究 (1989-2013) 数据的纵向队列研究.
- 包括65岁以上的成年人,他们的LVEF正常,以前没有HF诊断.
- 基线LBBB存在通过心电图确定; 考克斯比例危险模型评估结果.
主要成果:
- 在4541名参与者中,44名 (1.0%) 在基线时患有LBBB.
- 在5年内,LBBB与发生性HF风险增加了近5倍 (HR,4.98) 和LVEF下降的概率增加了4.7倍.
- 在患有LBBB.的人群中,没有观察到任何原因死亡风险的显著增加.
结论:
- 在结构正常的心脏的个体中,LBBB是发生HF和LVEF下降的重要预测因素.
- LBBB可以作为旨在预防心脏功能障碍和HF进展的干预措施的早期指标.
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