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Updated: Aug 5, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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BLIMP-1和CEACAM1协同调节人类Treg稳态,并控制异源GVHD的功能

Ying Ding1, Aixin Yu1, Milos Vujanac1

  • 1Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America.

JCI insight
|August 7, 2025
PubMed
概括

调节性T细胞 (Tregs) 控制免疫耐受性. BLIMP-1限制了人类Treg增殖,同时支持功能,与CEACAM1在IL-2反循环中工作,以调节Treg活动和扩张.

关键词:
适应性免疫是一种适应性免疫.自身免疫性疾病是一种自身免疫性疾病.这是一种自身免疫力.免疫学 免疫学 免疫学免疫治疗是一种免疫疗法.

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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