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Updated: Sep 12, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Published on: April 9, 2018

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固体支的衍生利用含有二硫化物功能组的碳酸盐连接带

Jagandeep S Saraya1, Derek K O'Flaherty1

  • 1Department of Chemistry, University of Guelph, Guelph, Canada.

Current protocols
|August 7, 2025
PubMed
概括

这项研究引入了一种新型的二硫化物链接剂,用于高效地在列上合成改性寡核酸,包括氨基和酸盐改性. 这种方法简化了DNA和RNA合成,并使得氨基酸-寡核酸合物的产生成为可能.

关键词:
在DNA/RNA合成过程中,类核酸的化学成分在列上保护和解除保护.降低性的链接器.固体支物的化学结构.

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...
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