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Updated: Sep 12, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

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一个阿基尼因开关驱动着CXCR7对β-arrestin的逐步激活

Jeong Seok Ji1, Yaejin Yun1, Tomasz Maciej Stepniewski2,3,4

  • 1Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.

PLoS biology
|August 7, 2025
PubMed
概括

β-arrestins (βarrs) 调节G蛋白合受体 (GPCR) 信号传递. 这项研究揭示了化学因子受体7 (CXCR7) 相互作用如何通过取代氨酸残留物来触发βarr2激活,从而破坏其核心结构的稳定.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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