德克萨米他在过敏性鼻炎的斯诺帕拉丁腺节阻塞中施用德克萨米他的作用:一个前性,随机化,单盲控制试验
Qinyue Luo1, Junyang Fang1, Yunqian Zhang2
1Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Nanjing, China; School of Anesthesiology, Xuzhou Medical University, Xuzhou, P.R. China.
Pain physician
|August 7, 2025
概括
超声导向的膜关节块 (SPGB) 有效治疗过敏性鼻炎 (AR) 症状,改善鼻腔气流. 与单独的布皮瓦卡因相比,添加德克萨米他到SPGB可能会提高短期治疗疗效.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
- 疼痛管理 疼痛管理
背景情况:
- 过敏性鼻炎 (AR) 是一种普遍的慢性疾病,影响生活质量.
- 超声导向的膜关节块 (SPGB) 是一种新兴的,微创性治疗方法,用于缓解AR症状.
- 德克萨米他在SPGB中对AR中自主神经调节的作用需要进一步研究.
研究的目的:
- 评估超声波引导的SPGB治疗过敏性鼻炎的疗效.
- 为了比较德克萨米他与SPGB相结合的临床有效性和不良反应与单独的布皮瓦卡因.
主要方法:
- 一项前性,随机的,单盲对照试验与84名AR患者进行.
- 患者每周接受超声波引导的SPGB治疗4周,交替侧面.
- 实验组接受了布皮瓦卡因与德克萨;对照组仅接受了布皮瓦卡因. 使用TNSS,VAS,RQLQ,TNRV,TNV和TNR进行了有效性评估.
主要成果:
- 两组患者在治疗后显著改善症状 (TNSS,VAS,RQLQ) 和改善鼻气流 (TNRV,TNV,TNR).
- 德克萨米他组在1周,1个月和3个月 (P <0.05) 显示出优异的短期疗效.
- 在6个月后,没有发现有效性的显著差异,尽管德甲组保持了较低的TNSS. 安全概况是可比的.
结论:
- 超声波引导的SPGB是一种安全有效的AR治疗方法,改善了症状和鼻腔气流.
- 加上皮质类固醇 (德克萨米他) 可能提供更好的短期治疗效益.
- 需要进一步的研究来探索最佳的皮质类固醇选择和导航技术.
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