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输液之外:在单克隆抗体治疗中对输液相关反应的现实洞察

Elise J Smolders¹, Elianne C S de Boer², Helle-Brit Fiebrich-Westra²

¹Department of Clinical Pharmacy, Isala Hospital, Zwolle, the Netherlands.

JCO oncology practice

|August 7, 2025

概括

与输液相关的反应 (IRR) 在现实环境中发生的比预期的更频繁的伊皮利马布加尼沃马布治疗. 适当的管理使患者能够安全地继续单克隆抗体 (mAb) 治疗.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药物监督药物监督药物监督

背景情况:

输液相关反应 (IRR) 是单克隆抗体 (mAb) 治疗的已知并发症.
对于内部回报率的精确机制和预测因素仍然不完全理解.
在各种mAbs中IRR发生率的真实数据有限.

研究的目的:

确定在接受特定单克隆抗体的患者中IRRs的真实发病率.
确定哪些mAbs与更高的IRR发生率有关.
为更好地了解临床实践中的IRR发生做出贡献.

主要方法:

在2021年1月至2022年6月期间,对692名接受了精选mAbs治疗的患者进行了回顾性分析.
包括mAbs:阿特佐利祖马布,贝瓦西祖马布,杜尔瓦卢马布,伊皮利穆马布,尼沃卢马布,帕尼图穆马布,潘布罗利祖马布,特拉斯图祖马布,珀图祖马布和修礼马布.
使用常用术语标准对不良事件 (CTCAE) 的IRR的分级.

主要成果:

总体而言,6.7%的患者经历了IRR.
利图西马布显示了最高的IRR发生率 (26%),其次是伊皮利穆马布加尼沃卢马布 (13%),尼沃卢马布的贡献很大.
这些发病率,特别是伊皮利穆马布/尼沃卢穆马布的发病率,超过了文献中以前报告的发病率.

结论:

伊皮利穆马布加尼沃卢马布的组合与这种现实世界队列中的IRR发生率高于预期.
有效地识别和管理IRR对于安全地继续mAb治疗至关重要.
这项研究强调了在临床实践中持续对mAbs进行药物监测的重要性.

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