在马来西亚,纳尔特雷克松用于患有兴奋剂使用障碍的患者:回顾性队列研究协议
Nor Asiah Muhamad1, Nur Hasnah Ma'amor1, Muhammad Arif Muhamad Rasat2
1Sector for Evidence-based Healthcare, National Institutes of Health, Ministry of Health, Selangor, Malaysia.
JMIR research protocols
|August 7, 2025
概括
这项研究调查了纳尔特雷克.
科学领域:
- 药理学和成医学 药理学和成医学
- 临床研究方法论 临床研究方法论
- 公共卫生 公共卫生
背景情况:
- 纳尔特雷克松是一种阿片类受体对抗剂,已被批准用于治疗海洛因和酒精.
- 自2011年以来,纳尔特雷已被用于非标签的兴奋剂使用障碍 (StUD) 治疗.
- 关于纳尔特雷克松对STUD的疗效的证据有限.
研究的目的:
- 为了确定使用和不使用STUD治疗纳尔特雷克松的患者与通常治疗 (TAU) 之间的戒断率.
- 评估纳尔特雷克松与在StUD和非StUD患者中维持治疗之间的关联.
- 为纳尔特雷克松在管理兴奋剂使用障碍中的作用提供证据.
主要方法:
- 使用从2011年1月到2023年12月的临床记录进行回顾性队列研究设计.
- 包括患有STUD或其他物质使用障碍的成年患者 (18-65岁).
- 单变量和时间序列分析以评估戒断和保留,比较纳尔德与TAU.
主要成果:
- 数据收集和分析计划在2026年1月之前完成.
- 该研究将报告招募和患者特征.
- 预计将产生关于纳尔特雷对禁欲和养的影响的发现.
结论:
- 纳尔特雷克松可能为StUD提供一种潜在的治疗途径,在缺乏特定药物的情况下.
- 调查结果可以为临床实践和公共卫生策略提供有关物质使用障碍的信息.
- 需要进一步的研究来澄清纳尔德在STUD治疗中的有效性,以及心理社会干预.
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