在美国的一项减少危害计划中,废水中使用物质的流行率与注射器的分布之间的相关性
Bikram Subedi1, Houston D Hampton2, Joshua Revell2
1Department of Environmental Sciences, Louisiana State University, Baton Rouge, LA, United States; Department of Chemistry, Murray State University, Murray, KY, United States.
The Science of the total environment
|August 7, 2025
概括
废水流行病学准确地追踪了社区中的药物使用情况,揭示了注射器服务计划主要为精神刺激剂和阿片类药物使用者提供服务. 这些数据可以增强降低危害的策略,减少过量死亡.
科学领域:
- 环境科学 环境科学
- 公共卫生 公共卫生
- 法医毒理学 法医毒理学
背景情况:
- 药物使用监测对于有效的降低危害策略至关重要.
- 基于废水的流行病学 (WBE) 提供了一个社区级,近乎实时的评估工具.
- 注射器服务计划 (SSP) 是干预和数据收集的关键点.
研究的目的:
- 评估使用WBE的SSP服务的社区中的物质使用模式.
- 评估WBE数据与SSP服务提供之间的相关性.
- 确定WBE在告知减少危害倡议方面的实用性.
主要方法:
- 在12个月内对精神兴奋剂,阿片类药物,阿片类药物使用障碍的药物,抗精神病药物,抗抑郁药物和大麻进行了WBE.
- 人均数量化药物消费量 (mg/d/1000人).
- 相关联的月度药物使用数据与月度注射器分发数字.
主要成果:
- 估计每月的消费量:甲基胺 (44,000剂量),氧化 (41,600剂量),可卡因 (9,600剂量) 和芬拉法辛 (19,000剂量).
- 每月注射器分配与个人药物使用之间没有相关性.
- 在WBE衍生药物类 (处方阿片类药物,精神刺激药物,阿片类药物) 和注射器分布 (R2=0.737到0.783) 之间发现了显著的相关性.
结论:
- WBE提供了关于社区物质使用的准确,近乎实时的数据.
- 这个社区的注射器使用主要是用于精神兴奋剂和阿片类药物.
- WBE是减少危害计划的宝贵补充工具,用于评估干预措施并减少过量死亡.
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