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Updated: May 5, 2026

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环境水样的基于效果的高通量选:专注于肝脏毒性途径和内分泌干扰

Olivia Lautan¹, Ssu-Ning Chen², Chin-Ching Lu²

¹Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Journal of hazardous materials

|August 7, 2025

概括

这项研究引入了评估地下水污染的创新框架. 通过结合先进的选方法和计算分析,它有效地识别和排名污染风险,以保护公众健康和环境.

科学领域:

环境毒理学环境毒理学
生物监测生物监测
计算毒理学计算毒理学

背景情况:

工业扩张增加了地下水污染,危及人类健康和生态系统.
传统的毒性测试范围和效率有限.
需要先进的方法来评估复杂的环境风险.

研究的目的:

开发和评估一种基于效果的框架,用于地下水毒性查.
整合高吞吐量查 (HTS),高含量查 (HCS),不良结果途径 (AOP) 和ToxPi分析.
为环境监测和风险评估提供全面的战略.

主要方法:

利用基于细胞的测试来检测细胞毒性,反应性氧物种 (ROS) 生产和亡.
评估内分泌干扰作用,包括类固醇激素产生的改变.
应用计算ToxPi分析来整合多个终点和排名样本风险.

主要成果:

鉴定了具有潜在肝脏和脏毒性的地下水样本.
检测到显著的细胞毒性,增加的ROS,亡和内分泌干扰.
ToxPi分析成功地根据综合毒性得分对样品进行了排序.

结论:

综合框架为地下水毒性查提供了一种全面而有效的方法.
将HTS/HCS与AOP和计算分析相结合,可以加强环境监测.
该战略支持改善对地下水污染物的公共卫生保护.

关键词:

基于效果的方法 (EBM)内分泌干扰干扰内分泌系统高通量选 (HTS) 是一种高通量选.肝脏毒性肝脏毒性我们的ToxPiPi.

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