中国东部新兴的增塑剂:人口暴露和脂质代谢相关的健康风险
Wenyuan Lu1, Qianyu Chen2, Jun Huang1
1School of Public Health, Nanjing Medical University, Nanjing 210094, People's Republic of China.
Journal of hazardous materials
|August 7, 2025
概括
六种新兴的增塑剂,包括三三 (THTM),与受损的脂质代谢有关. THTM可能会对健康构成风险,这凸显了进一步研究塑化剂暴露及其影响的必要性.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 毒理学 毒理学 毒理学
背景情况:
- 新兴的增塑剂越来越多地出现在环境和人类样本中.
- 关于人类暴露和与这些化合物相关的健康风险的数据有限.
研究的目的:
- 通过量化代谢物和血清脂质生物标志物来评估人类对新出现的增塑剂的暴露.
- 探索塑化剂与脂质代谢之间的关联.
- 为了解塑化剂引起的潜在代谢干扰提供见解.
主要方法:
- 在中国江苏省对1514名参与者的生物监测.
- 斯皮尔曼的相关性来评估年龄和性别的影响.
- 一般化添加剂模型和基于量子的g计算用于关联和联合效应分析.
- 贝叶斯基准剂量分析用于风险评估.
主要成果:
- 六种增塑剂 (二甲基烟酸,二甲基酸,三基三酸,二甲基酸,二甲基酸异构体) 与脂质生物标志物有显著的关联.
- 已确定三基三甲酸 (THTM) 作为潜在的健康风险 (危险系数> 1).
- 研究结果表明,这些可塑剂可以破坏脂质代谢.
结论:
- 确定了六种与脂质代谢中断相关的新兴塑化剂.
- 三基三甲酸 (THTM) 可能对一般人群构成健康风险.
- 塑化剂代谢物和脂质生物标记物的同时评估为研究和风险管理提供了一种新的方法,特别是在LMICs.
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