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Updated: Sep 12, 2025

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

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对氨酸介导的WIN位点识别的结构洞察力揭示了WDR5结合的另一个"AK"动机

Yan Pan1, Hao Li1, Lihong Chen1

  • 1School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China.

Biochemical and biophysical research communications
|August 7, 2025
PubMed
概括

WD重复含有蛋白5 (WDR5) 与氨酸相互作用,而不仅仅是氨酸,在一个新的WIN动机. 这一发现重新定义了WDR5结合,并为治疗抑制剂提供了新的点.

关键词:
阿尔法Fold3是什么意思晶体结构 晶体结构在 MBD3C 里面,你会看到 MBD3C.这是WDR5的WDR5.在WIN图案中,使用的是WIN图案.

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