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实际与理想的捐赠者体重在计划骨髓收获时

Rui Murahashi¹, Shin-Ichiro Fujiwara¹, Daisuke Minakata²

¹Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan; Division of Cell Transplantation and Transfusion, Jichi Medical University, Tochigi, Japan.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

|August 7, 2025

概括

理想体重 (IBW) 和实际体重 (ABW) 在估计造血干细胞 (HSC) 产量方面没有显著差异. 这表明目前基于ABW的收获做法适合所有捐赠者,包括那些患有肥胖症的人.

科学领域:

血液学血液学血液学
移植医学移植医学移植医学
肥胖问题研究研究

背景情况:

供体选择和收获量计算通常依赖于实际体重 (ABW).
在肥胖个体中,由于脂肪组织含量较高,ABW可能会高估骨髓体积.
这引发了关于血造干细胞 (HSC) 产量估计的最佳体重指标的问题.

研究的目的:

为了评估理想体重 (IBW) 是否比ABW更准确的预测器来估计所需的HSC产量.
评估收获的HSC和每位ABW和IBW的数量之间的相关性.
为了检查血红蛋白下降和相对于ABW或IBW的收获量之间的关系.

主要方法:

分析了157名献血者 (106名男性,51名女性) 的数据,其BMI≥22.
用ABW和IBW计算的收获HSC (总核细胞,CD34+HSC) 和收获量之间的相关性分析.
血红蛋白水平下降和每ABW或IBW收获量之间的相关性分析.

主要成果:

在细胞计数 (核细胞总数,CD34+ HSCs) 和每个ABW或IBW收获量之间的相关性中没有发现显著差异.
在所有捐赠者和肥胖捐赠者之间,在血红蛋白下降和每ABW或IBW收获量之间的相关性中没有观察到显著差异.
每个ABW的收获量没有被发现过多.

结论:

无论是IBW还是ABW,都没有在估计HSC收益率方面表现出对另一方的显著优势.
目前使用ABW用于HSC产量估计的做法似乎是适当的,而不是过度的,即使在肥胖的捐赠者中也是如此.
这些发现支持在HSC收获的捐赠者管理中继续使用ABW.

关键词:

真正的体重实际体重.骨髓采集骨髓采集造血干细胞是造血干细胞的组成部分.造血干细胞移植造血干细胞移植理想的体重是理想的体重.

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