系统性免疫炎症指数与非老年糖尿病成年人全因和心血管疾病死亡率之间的关联
Bing Hu1, Tong Liu1, Yanxiang Sun1
1Department of Cardiology, Zhongshan City People's Hospital, Zhongshan, Guangdong, China.
较高的全身免疫炎症指数 (SII) 水平表明非老年糖尿病成年人心血管疾病 (CVD) 和全因死亡风险增加. 这一发现凸显了SII作为这种人群中死亡风险分层的潜在生物标志物.
科学领域:
- 心血管医学 心血管医学
- 糖尿病研究 糖尿病研究
- 炎症生物标志物 炎症生物标志物
背景情况:
- 系统性免疫炎症指数 (SII) 是已知的心血管疾病 (CVD) 和死亡率的预测指标.
- 它与非老年糖尿病成年人全因和心血管疾病死亡率的特定关联需要进一步调查.
研究的目的:
- 调查SII与美国非老年糖尿病成年人全因和心血管疾病死亡率之间的关系.
- 使用限制立方 (RCS) 探索潜在的非线性关联.
主要方法:
- 来自NHANES (20012018) 数据集的4680名参与者的分析.
- 利用考克斯的比例危险模型和子组分析来评估死亡风险.
- 雇佣RCS来研究SII和死亡结果之间的非线性关系.
主要成果:
- 较高的SII水平与心血管疾病死亡率 (HR = 3.05) 和全因死亡率 (HR = 1.97) 的增加有显著关联.
- 小组分析证实了这些协会的稳定性.
- RCS揭示了与所有原因死亡率的非线性关联以及与心血管疾病死亡率的线性关联.
结论:
- 升高的SII水平与非老年糖尿病成年人患心血管疾病和全因死亡率的风险更高有关.
- 在这个人口群体中,SII可以作为死亡率的有价值的预后标记.
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