适应性功能和行为问题的发展轨迹 在患有同时发生结核硬化综合症和自闭症谱系障碍的儿童中,有和没有发作
Lynnel C Goodman1, Melissa A Richard2, John P Woodhouse2
1Louis A. Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), Houston, Texas; Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Pediatric neurology
|August 7, 2025
概括
患有结核性硬化综合体 (TSC) 和自闭症谱系障碍 (ASD) 的儿童在36个月时表现出较差的社会和情感发展. 对于有针对性的干预措施来说,早期检测ASD的TSC发育问题至关重要.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科神经学 儿科神经学
- 发展心理学是发展心理学.
背景情况:
- 结核性硬化综合体 (TSC) 增加了适应性和行为问题的风险,包括自闭症谱系障碍 (ASD).
- 了解患有TSC,有或没有自闭症儿童的发育轨迹至关重要.
研究的目的:
- 评估TSC儿童的适应性和行为发展轨迹.
- 为了比较36个月的TSC患有ASD诊断的和没有ASD诊断的儿童.
主要方法:
- 使用穆伦早期学习量表,维尼兰适应性行为量表和儿童行为检查清单,对患有TSC的婴儿进行纵向评估.
- 与36个月的ASD诊断相关的18,24和36个月的功能分析.
主要成果:
- 患有TSC和最终ASD诊断的儿童从18个月起表现出适应性缺陷,特别是在36个月的社会功能方面.
- 36个月后,TSC和ASD儿童的行为和情绪问题更严重,即使调整了发育水平.
- 扣押负担无法解释这些观察到的差异.
结论:
- 与没有ASD的同龄人相比,患有TSC和ASD的儿童在36个月内表现出明显较差的社会适应能力和情绪/行为功能.
- 早期识别这一群体的发展问题至关重要.
- 针对性治疗对于改善TSC和ASD儿童的治疗结果至关重要.
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