患有喘或过敏性鼻炎的患者中阻塞性睡眠呼吸暂停的频率:系统性审查和元分析
Nuno Barros Ferreira1, Alexandra Ponte2, Ana Castelo Grande3
1Department of Pulmonology, Unidade Local de Saúde do Tâmega e Sousa, Portugal; Faculty of Medicine of Porto University, Portugal.
Sleep medicine
|August 7, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 在过敏性鼻炎 (AR) 或喘患者中更常见. 中度至重度喘与OSA显著相关,需要进一步调查.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 喘和过敏性鼻炎 (AR) 是常见的呼吸道疾病.
- 这些情况经常与阻塞性睡眠呼吸暂停 (OSA) 并存.
研究的目的:
- 为了确定喘或AR是否与OSA更高的患病率有关.
- 研究呼吸道疾病和睡眠呼吸暂停之间的关联.
主要方法:
- 12项横截面和队列研究的系统综述和元分析.
- 包括19203名成年参与者,通过多睡眠学诊断出OSA.
- 使用ROBINS-E和GRADE框架评估偏差风险和证据确定性.
主要成果:
- 在AR患者中发现OSA的频率更高 (OR=2.4).
- 喘和OSA之间的关联在整体上较弱 (OR=1.4),但在中度至重度喘中显著 (OR=10.1).
- 喘患者的呼吸暂停-呼吸暂停指数增加,氧气不和指数增加,平均氧气和率降低.
结论:
- 在AR,中度至重度喘和OSA之间存在关联.
- 建议进行前性研究,以评估喘和AR患者的OSA风险,并考虑喘的严重程度.
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