相关实验视频

Updated: May 5, 2026

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

准备,结构特征和控制释放基于原生/修改的库祖粉的布亚林载荷复合物和凝珠

Wenqing Zhu¹, Mengli Liu², Hanwei Chi³

¹Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, Shandong, China; Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Liège, Passage des déportés 2, B-5030 Gembloux, Belgium.

|August 7, 2025

概括

经过修改的库祖粉复合物和凝珠显示出改善的封装和持续释放的 puerarin. 这些进步提供了更好的保护和有效物质的有针对性的交付.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
生物技术是生物技术.

背景情况:

库德祖粉是活性物质的潜在载体材料.
开发可控释放的稳定配方对于药物输送至关重要.
表面活性剂和交联剂可以改变材料的特性.

研究的目的:

为了准备和表征库祖粉基复合物和凝珠.
评估Span 80修改对这些材料的影响.
通过使用这些配方来评估puerarin的受控释放.

主要方法:

复杂制剂的抗溶剂沉.复杂制剂的抗溶剂沉.
藻酸盐与离子交联,形成凝珠.
系统地研究结构,质,形态和释放性质.

主要成果:

"Span 80"修改提高了封装效率 (71.12%) 和复合物的热稳定性.
经过修改的复合体显示出统一的球形结构和减少的结晶性.
经过修改的凝珠表现出更高的封装效率 (62.38%),更好的纹理和胀稳定性.
修改复合体和凝珠都显示出增强的持续释放的 puerarin.

结论:

"Span 80"修改显著增强了库祖粉基复合物和凝珠的性能.
这些改性材料显示出保护活性物质的巨大潜力.
开发的配方能够有针对性和受控地释放皮亚林.

关键词:

复杂的复杂的复杂.有控制释放的释放.凝珠子凝珠子库德祖粉库德祖粉普埃拉里娜是一个小女孩.跨度 80 跨度 80 跨度结构性表征结构性表征

更多相关视频

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota

Published on: May 23, 2025

相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...