组织因子在瘤微环境和向治疗中的作用
Ying Yan1, Yifan Li1, Dan Zou1
1The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China; Key Laboratory of the Digestive System Tumors of Gansu Province, The Second Hospital and Clinical Medical School, Lanzhou, China.
Biochimica et biophysica acta. Reviews on cancer
|August 7, 2025
概括
组织因子 (TF) 启动血液凝固并驱动癌症的生长. 向TF可以通过改变瘤微环境 (TME) 来提高抗癌免疫力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 组织因子 (TF) 是凝血级联的关键发起者.
- TF在癌症的进展,转移和免疫逃避中发挥着重要作用.
- 瘤微环境 (TME) 越来越被认为是癌症治疗反应的关键因素.
研究的目的:
- 综合审查TF在TME中的多方面的角色.
- 为了阐明TF介导的癌症免疫抑制机制.
- 评估针对TF的新策略,以克服治疗耐药性.
主要方法:
- 对临床前和临床研究的系统文献综述.
- 在各种癌症类型中分析TF表达和功能.
- 评估针对TF的治疗方法及其对TME和抗瘤免疫力的影响.
主要成果:
- TF通过前凝和非静血路径促进瘤生长和转移.
- 在TME中,TF信号传递通过招募髓状腺衍生抑制细胞和抑制T细胞功能,促进免疫抑制.
- 针对TF在临床前模型中表现出有希望,增强免疫细胞透率并提高治疗疗效.
结论:
- TF是瘤微环境的关键调节者,促进免疫逃避和治疗耐药性.
- 针对TF是一种有希望的策略,可以重编程TME并增强抗癌免疫力.
- 为了改善癌症治疗结果,需要对TF向疗法的进一步临床研究.
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