日常饮食频率与夜间禁食持续时间和NHANES 2005-2018抑郁症之间的U形关联
Yan Chen1, Ruilan Gong1, Qianzhu Li2
1Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150086, PR China.
Journal of affective disorders
|August 7, 2025
概括
吃得太少或太频繁,以及短时间或长时间的禁食,与更高的抑郁风险有关. 这些饮食模式,每日饮食频率 (DEF) 和夜间禁食持续时间 (NFD) 都会影响心理健康.
科学领域:
- 营养精神病学 营养精神病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在当前的研究中,关于日常饮食频率 (DEF) 与夜间禁食持续时间 (NFD) 和抑郁症之间的联系存在不一致.
- 本研究旨在澄清DEF,NFD和抑郁症之间的关联.
研究的目的:
- 调查日常饮食频率 (DEF) 和夜间禁食持续时间 (NFD) 与抑郁症之间的关系.
- 在这些关联中识别潜在的调解因素和效果修饰因素.
主要方法:
- 分析了2005-2018年国家健康和营养检查调查 (NHANES) 的29,035名参与者.
- 根据患者健康问卷-9 (PHQ-9) 定义的抑郁症得分≥10.
- 使用加权后勤回归,限制立方线和调解分析.
主要成果:
- 每日饮食频率 (DEF) 非常低 (≤3) 和非常高 (≥4.6) 都与抑郁症风险增加有关.
- 短 (≤10.8h) 和长 (≥14.9h) 的夜间禁食持续时间 (NFD) 都显示出更高的抑郁风险.
- 血液尿素 (BUN) 和血球蛋白 (Glo) 调解了这种关联,在每日能量摄入量较低的人群中观察到更显著的影响.
结论:
- 每日进食频率 (DEF) ≤3或≥4.6次,夜间禁食时间 (NFD) ≤10.8或≥14.9小时,独立地与抑郁症风险增加有关.
- 这些发现强调了定期饮食模式和适当的禁食时间对心理健康的重要性.
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