长效药物输送系统:现状和未来前景
Eneko Larrañeta1, Juan Domínguez-Robles2
1School of Pharmacy, Queen's University Belfast, Lisburn Road 97, Belfast BT9 7BL, UK.
Drug discovery today
|August 7, 2025
概括
长效药物输送系统 (LADDS) 通过提供可控的,延长的药物释放来提高治疗效率和患者的坚持. 可注射和可植入LADDS的创新有望改善慢性疾病的治疗结果.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送技术 药物输送技术
背景情况:
- 传统的药物输送方法往往导致药物度的波动,导致治疗效率和安全性低于最佳,特别是在治疗慢性疾病时.
- 持续的药物释放对于改善治疗结果和患者长期治疗中的服药性至关重要.
研究的目的:
- 审查可注射和可植入的长效药物输送系统 (LADDS) 的当前进展.
- 探索新兴技术和下一代LADDS发展的未来方向.
主要方法:
- 对已批准和正在研究的长效注射和植入药物输送配方的现有文献的审查.
- 分析创新方法,包括纳米悬浮,微球,现场成型系统,预成型植入物,热反应凝,聚合物药物合物,前期药物,3D打印和容器植入物.
主要成果:
- 目前的LADDS包括纳米悬浮,PLGA微球,油基注射,现场成型系统和预成型植入物,提供可控和延长的药物释放.
- 未来的LADDS技术包括热敏凝,聚合物药物合物,前期药物,3D打印应用,以及使用半透膜的容器植入物.
结论:
- 与传统方法相比,长效药物输送系统显著提高了药物的有效性,安全性和患者的坚持.
- 持续的多学科合作对于推动创新的长效疗法的开发和临床转化至关重要.
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