在口服葡萄糖耐受性测试期间产妇低血糖是否可以预测不良妊娠结果?
Yongying Bai1, Ya Xi2, Binbin Yin1
1Department of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
概括
在口服葡萄糖耐受性测试 (OGTT) 期间患有低血糖的孕妇面临不良妊娠结果的风险增加,包括低出生体重和妊娠年龄小的新生儿. 密切监测对于管理这些风险至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 内分泌学 在内分泌学.
背景情况:
- 孕期糖尿病 (GDM) 查通常使用75克口服葡萄糖耐受性测试 (OGTT).
- 虽然高血糖症得到了充分的研究,但在怀孕期间OGTT期间低血糖症的影响不太清楚.
- 识别与OGTT定义的低血糖症相关的风险对于优化孕产妇和新生儿护理至关重要.
研究的目的:
- 调查75克OGTT期间低血糖和不良妊娠结果 (APO) 之间的关联.
- 为了确定怀孕期间低血糖是否对新生儿出生体重和生长参数构成风险.
主要方法:
- 追溯分析了23,576名接受75克OGTT的孕妇.
- 低血糖症被定义为葡萄糖值<3.9 mmol/L.
- 使用后勤回归和趋势分析,比较低血糖和正常血糖组之间的孕产妇和产周结局.
主要成果:
- 低血糖症发生在7.07%的女性中,这些女性年轻,体重指数较低.
- 低血糖症与较低的出生体重,低出生体重 (LBW) 和妊娠年龄 (SGA) 小的新生儿的增加率有关.
- 相反,低血糖显示出对妊娠年龄大 (LGA) 和宏的保护作用,尽管在调整后仍然与SGA相关.
结论:
- 75克OGTT期间的低血糖与新生儿出生体重变化有关,特别是增加SGA和LBW.
- 低血糖症的严重程度显示了SGA的积极趋势和LGA的负面趋势.
- 被OGTT检测到的低血糖症的孕妇需要对不良周产期结果进行警监测.
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