血多不和脂肪酸与代谢综合征风险之间的关联:在亚洲多民族人口中进行的前性和调解研究
Yu Qi Lee1, Bee Choo Tai1, Xueling Sim1
1Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
摄入更多的多不和脂肪酸 (PUFA),包括omega-3和omega-6,与降低代谢综合征 (MetS) 风险有关. 炎症可能在这种保护作用中发挥作用,特别是对于酸.
科学领域:
- 营养流行病学 营养流行病学
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢综合征 (MetS) 是一个日益严重的健康问题,特别是在亚洲人群中.
- 多不和脂肪酸 (PUFA) 在MetS中的预防作用需要进一步研究.
研究的目的:
- 检查血n-3和n-6PUFA水平变化与MetS发病率之间的关联.
- 探索在基线PUFA和MetS发病率之间的关系中炎症的调解作用.
主要方法:
- 对1303名成年人 (21至75岁) 进行前性队列研究,随访时间中位数为6年.
- 通过核磁共振测量人类学,血压,血PUFA和糖蛋白乙 (GlycA).
- 通过≥3个组成部分定义的MetS:腹部肥胖,高甘油三,低HDL,高血压,高禁食葡萄糖. 分析了使用混合效应逻辑回归和使用一般化结构方程建模调解的关联.
主要成果:
- 较高的总n-3PUFA,多可沙赫酸 (DHA),总n-6PUFA和酸 (LA) 的血水平与MetS发生率相反相关 (所有P<0.001).
- 升高的PUFA水平与单个MetS成分的更低的几率相关,包括甘油三,高密度胆固醇,血压和禁食葡萄糖.
- 炎症标志物GlycA显著调解了基线总n-6PUFA (20%) 和LA (50%) 和MetS发病率之间的关联.
结论:
- 血中n-3,DHA,n-6PUFA和LA度的增加与发展MetS的风险降低有关.
- 减少系统性炎症可能会调解林诺基酸对MetS的保护作用,这需要进一步研究.
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