氨酸丰富补充剂的营养影响:通过人工智能 (AI) 增强的肌肉超声波来评估蛋白质类型,以高热量,高蛋白支持
Juan José López-Gómez1, Jaime González-Gutiérrez1, Olatz Izaola-Jauregui1
1Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación en Endocrinología y Nutrición, Universidad de Valladolid, Spain.
Clinical nutrition ESPEN
|August 7, 2025
概括
氨酸丰富的口服营养补充剂 (ONS) 改善了营养不良患者的身体组成. 这项研究发现,与标准的ONS相比,leucine-ONS的相角和肌肉厚度更好.
科学领域:
- 临床营养学 临床营养学
- 身体组成分析 身体成分分析
- 肌肉新陈代谢 肌肉新陈代谢
背景情况:
- 营养不良会对慢性病患者的身体功能和身体组成产生负面影响.
- 氨酸补充剂对改善身体组成和临床结果有希望.
- 患有营养不良风险的患者需要有效的营养干预措施.
研究的目的:
- 评估氨酸丰富的口服营养补充剂 (ONS) 对营养不良患者的营养状况的影响.
- 为了比较氨酸丰富的ONS与标准ONS对身体组成和肌肉健康的影响.
- 在临床环境中确定氨酸补充剂的潜在益处.
主要方法:
- 未来的观察性研究与两个队列超过3个月.
- 干预包括氨酸丰富的ONS (20%蛋白质,100%乳清,3g氨酸) 和标准的ONS.
- 通过人体测量,生物电阻分析,AI肌肉超声波和手握强度评估营养状况.
主要成果:
- 与标准ONS组相比,Leucine-ONS组表现出相角 (+2.08%) 和直骨肌肉厚度 (+1.72%) 的显著改善.
- 多变量分析将Leucine-ONS与改善相角 (OR=2.41) 和减少肌内脂肪 (OR=2.24) 联系起来.
- 营养不良影响了142名参与者的90.1%;34.5%患有肉症,癌症是最常见的疾病 (30.3%).
结论:
- 与营养不良患者的标准ONS相比,氨酸丰富的ONS在增强身体组成,特别是相角和肌肉厚度方面表现出更高的有效性.
- 这些发现支持使用氨酸丰富的ONS来改善营养状况和身体成分.
- 建议进行进一步的随机对照试验,以验证这些结果,并评估长期的临床和功能结果,承认观察设计和组异质性.
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