在患有癌症的儿童中,对COVID-19疫苗接种的免疫反应
Amy Body1,2, Luxi Lal1,2, Peter Downie1,2,3
1Monash Health, Department of Oncology, Clayton, VIC, Australia.
Pediatrics
|August 7, 2025
概括
患有癌症的儿童对COVID-19疫苗接种有很好的免疫反应 (BNT162b2). 大多数患者产生中和抗体和T细胞反应,这表明在癌症治疗期间接种疫苗是安全有效的.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
背景情况:
- 接受癌症治疗的年轻患者面临严重COVID-19的更高风险.
- 有限的数据存在于这种脆弱人群中对COVID-19疫苗的免疫反应.
研究的目的:
- 评估BNT162b2COVID-19疫苗在患有癌症的儿童和青少年中的免疫性和安全性.
- 评估儿童癌症患者接种疫苗后的抗体和T细胞反应.
主要方法:
- 一项前性队列研究包括113名患有癌症的儿童和青少年 (5-19岁),接受2或3剂BNT162b2.2.
- 测量了中和抗体 (NAb) 标位,T细胞反应 (干扰素-γ) 和结合抗体标位.
- 系统地收集安全结果和不良事件.
主要成果:
- 2剂后,66%的患者呈阳性NAb反应 (≥1:20),在3剂后增加到80%.
- 在2剂后的59%,在3剂后的74%,观察到T细胞反应.
- 副作用大多是轻度至中度和短暂的,不会延迟癌症治疗.
结论:
- 在大多数患有癌症的儿童中,BNT162b2 COVID-19 疫苗会引起显著的免疫反应,即使在积极治疗期间也是如此.
- 在癌症治疗完成之前,不应该推迟接种COVID-19疫苗.
- 研究结果支持在儿童癌症患者中使用COVID-19疫苗接种,并可能在癌症治疗期间为其他儿童疫苗接种策略提供信息.
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