怀孕期间温暖自身抗体的临床意义
Emmanuel A Fadeyi1, Joshua Cox-Jones1, Amit K Saha1
1Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Transfusion medicine (Oxford, England)
|August 7, 2025
概括
怀孕引起的温暖自身抗体通常对母亲和婴儿无害. 虽然它们的检测可能表明潜在的风险,但这项研究在研究的患者队列中没有发现临床并发症.
科学领域:
- 免疫学 免疫学 免疫学
- 产科 产科 产科 产科 产科
- 围产儿医学 围产儿医学
背景情况:
- 有限的研究存在于怀孕期间温暖的自身抗体的临床意义.
- 潜在的胎儿风险与IgG自身抗体穿越胎盘屏障的能力有关.
研究的目的:
- 确定在孕妇中发现的温暖自身抗体的临床意义.
- 评估怀孕诱导的温暖自身抗体对孕产妇和胎儿的结果的影响.
主要方法:
- 具有抗体查阳性和温暖自身抗体诊断的产科患者的回顾性审查 (2016年8月 - 2023年10月).
- 包括直接抗球蛋白试验 (DAT) 和阳性病例的酸盐分析.
- 临床数据的统计分析,包括血型,血红蛋白和妊娠年龄.
主要成果:
- 在23510名孕妇中,812名 (3.5%) 的抗体查结果为阳性.
- 只有16名患者 (<2.0%) 确实有温暖的自身抗体.
- 在这16名患者中,没有发现过温暖自身抗体的病史;14/16名母亲和新生儿没有经历过自身免疫血清性贫血 (AIHA) 或胎儿和新生儿血清性疾病 (HDFN) 等不良结果.
结论:
- 怀孕引起的温暖自身抗体似乎对大多数母亲和婴儿构成最小的风险.
- 虽然检测需要考虑潜在的风险,但这个队列没有出现临床并发症.
- 进一步监测可能是有益的,但整体预后是有利的.
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