选择性局部麻醉对刚性隐形眼镜初始舒适度的影响
Maria Navascues-Cornago1, Carole Maldonado-Codina1, Michael L Read1
1Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, United Kingdom.
概括
选择性眼球表面麻醉显示,当上眼边缘结膜麻木时,最初的刚性隐形眼镜舒适度大大提高. 这表明上眼在隐形眼镜不适中起着关键作用.
科学领域:
- 眼科医生 眼科 眼科
- 眼镜测量是指眼睛的测量.
- 感官科学 感官科学
背景情况:
- 隐形眼镜不适的确切感官来源尚未得到充分理解.
- 调查不同眼睛表面组织对不适的贡献对于改善镜片设计和可穿戴性至关重要.
研究的目的:
- 确定角膜,上眼边缘结膜和下眼边缘结膜对刚性隐形眼镜不适的相对贡献.
- 评估一种新的技术,使用选择性局部麻醉来区分感官输入与眼睛表面位置.
主要方法:
- 一项随机的,面具对象的,对侧眼试点研究与10名参与者进行.
- 用Cochet-Bonnet美学计测量眼睛表面的机械灵敏度.
- 对三个位置 (角膜,上/下眼边缘连接膜) 之一施加选择性局部麻醉 (普罗西米塔卡因化物0.5%) 或安慰剂 (盐水),然后重新测量灵敏度和带有舒适度评分的刚性隐形眼镜佩戴.
主要成果:
- 选择性麻醉显著降低了针对性部位的敏感性,而不会影响其他部位.
- 当角膜或下眼边缘结膜被麻醉时,没有观察到舒适度的显著差异.
- 与安慰剂相比,当上眼边缘结膜被麻醉时,报告了舒适度的显著改善.
结论:
- 选择性局部麻醉是一种有效的方法,可以从特定的眼睛表面区域中分离感官贡献.
- 刚性隐形眼镜的初始舒适性似乎受到上眼边缘结膜的相互作用的显著影响.
- 这种技术有可能进一步研究刚性和软性隐形眼镜不适的机制.
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