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肠道微生物群通过胺衍生代谢物减轻银纳米颗粒的生殖毒性

Jing-Xi Gong¹, Xin-Lei Wang¹, Chen-Xin Lin¹

¹State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing, Jiangsu Province, China.

Nature communications

|August 7, 2025

概括

肠道细菌可以排毒银纳米粒子 (AgNPs). 将Pseudomonas mendocina引入Caenorhabditis elegans中拯救了由AgNPs引起的生殖毒性,突出了微生物群.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
微生物学微生物学

背景情况:

银纳米粒子 (AgNPs) 构成环境和健康风险,需要采取减少暴露的策略.
生物体水平的排毒方法至关重要,因为AgNP暴露往往是不可避免的.
肠道微生物群在宿主健康中起着重要作用,并可能影响纳米粒子毒性.

研究的目的:

研究肠道微生物群的潜力,以减轻AgNPs的不良影响.
为了比较AgNPs对带有和没有肠道微生物殖民的线虫的影响.

主要方法:

引入细菌菌株进入Caenorhabditis elegans的肠道.
在殖民和无菌线虫中对AgNP毒性的比较.
对基因表达和代谢概况的分析.
确定涉及毒性减轻的关键代谢物.

主要成果:

AgNPs显著损害了线虫的繁殖,这是一个敏感的毒性终点.
与Pseudomonas mendocina的殖民拯救了AgNP诱导的生殖毒性.
伪虫蒙多西纳抑制了AgNP触发的不良结果途径中的关键事件.
鉴定出两种硫胺衍生代谢物4-甲基-5-硫胺乙醇和硫胺单酸盐对于降低AgNP生殖毒性至关重要.

结论:

肠道微生物群,特别是Pseudomonas mendocina,可以有效地减轻Caenorhabditis elegans中的银纳米颗粒的生殖毒性.
胺衍生代谢物在这种保护机制中起着关键作用.
微生物群操纵为管理纳米粒子毒性提供了一个有希望的策略.

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