血清Trim24在动脉样硬化患者中的临床诊断价值
Yuchao Jiang1, Dejin Ou2, Jinzhu Huang1
1Department of Cardiovascular Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.
Scientific reports
|August 7, 2025
概括
动脉样硬化 (AS) 患者的血清Trim24水平升高,与疾病严重程度相关. Trim24显示出强大的诊断潜力,用于识别AS及其进展.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 心血管研究研究心血管研究
背景情况:
- 动脉样硬化 (AS) 的发病过程涉及复杂的炎症和代谢过程.
- 三方基因含蛋白24 (Trim24) 在AS中的作用在很大程度上仍未被描述.
- 研究用于AS诊断和严重程度评估的新生物标志物至关重要.
研究的目的:
- 为了评估血清Trim24在动脉样硬化中的诊断价值.
- 评估血清Trim24水平与AS疾病严重程度之间的关联.
- 探索Trim24,sCD163和AS进展之间的关系.
主要方法:
- 对137名AS患者和137名健康对照进行前性病例控制研究.
- 用ELISA测量的血清Trim24和sCD163水平.
- 后勤回归和ROC曲线分析用于确定诊断性能和独立的风险因素.
主要成果:
- 血清Trim24水平在AS患者中显著更高,与疾病严重程度相关 (严重的AS,严重的狭窄).
- 在Trim24中,AS的诊断准确度高 (AUC=0.928) 和严重程度.
- 血清sCD163水平在AS患者中较低,与Trim24相反相关,并显示了中度的诊断价值.
结论:
- 血清Trim24升高是AS和疾病严重程度的独立风险因素.
- Trim24显示出作为动脉样硬化的诊断生物标志物的巨大潜力.
- 需要在更大的群体中进行进一步的研究,以验证Trim24在AS中的作用.
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