通过多中心静止状态fMRI发现的神经成像生物标志物的计算机制,fMRI连接性变异概况
Okito Yamashita1,2, Ayumu Yamashita3,4, Yuji Takahara3
1RIKEN Center for Advanced Intelligence Project, Tokyo, Japan. okito.yamashita@riken.jp.
Molecular psychiatry
|August 7, 2025
概括
使用静止状态功能连接 (rsFC) 开发用于精神疾病的可靠生物标志物具有挑战性. 这项研究引入了对 rsFC 变异的新方法,提高了个体级别诊断生物标志物的准确性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物标志物开发 生物标志物开发
背景情况:
- 休息状态功能连接 (rsFC) 在精神疾病生物标志物方面表现有前途.
- 目前的rsFC生物标志物缺乏个人级别的临床可预测性,可概括性和稳定性.
研究的目的:
- 开发一种新的方法来分析个体功能连接 (FC) 变异.
- 提高精神疾病多连接生物标志物的准确性和通用性.
主要方法:
- 利用了来自29个站点的900名参与者的超过1500次静止状态数据.
- 对于每个单独的FC,估计与疾病相关的和与疾病无关的FC变化.
- 训练有素的多连接生物标志物使用集体稀疏分类器.
主要成果:
- 确定了个体 rsFC 的层次变化,包括主体内部,个体差异,疾病影响和扫描仪/协议因素.
- 稀缺的机器学习算法有效地逆转了这些变化.
- 生物标志物的性能改善归因于抑制与疾病影响相关的个体和个体内变异.
结论:
- 拟议的综合性分析方法为开发可靠的,个体级别的精神疾病生物标志物提供了一个工具.
- 这种方法提高了基于FC的生物标志物的稳定性和通用性.
更多相关视频
相关概念视频
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).


