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Updated: Sep 12, 2025

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对聚合酶催化FAD封闭C型肝炎病毒RNA的结构洞察力

De-Ping Wang1, Rong Zhao1, Wen-Shu Hu1

  • 1Department of Cardiology, The First Hospital of Shanxi Medical University, MOE Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, China.

Nature communications
|August 7, 2025
PubMed
概括

型肝炎病毒RNA聚合酶NS5B使用黄氨酸二核酸 (FAD) 进行5'封闭. 特定的氨基酸和RNA相互作用稳定了这一过程,提供了新的抗HCV治疗点.

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