动脉硬会缓解NfL和认知之间的联系:IGNITE研究
Amani M Norling1,2, Lewis A Lipsitz1,2, Alyssa B Dufour1,2
1The Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
概括
较高的动脉硬度会放大神经丝光对老年人认知功能的负面影响. 这表明血管衰老可能会恶化与神经轴突退化相关的认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 心血管医学 心血管医学
背景情况:
- 动脉硬度,通过心骨脉冲波速率 (cfPWV) 测量,以及血神经丝光 (NfL) 分别是血管和神经轴的衰老指标.
- 无论是cfPWV还是NfL都独立地与老年人的认知能力下降有关.
- cfPWV对NfL和认知功能之间的关系的潜在协同效应在很大程度上仍未被探索.
研究的目的:
- 调查较高的cfPWV是否会加剧NfL水平和认知表现之间的关联在认知不受损的老年人中.
- 探索血管衰老和神经轴突退化的标志物对认知功能的综合影响.
主要方法:
- 对570名认知不受损的老年人进行横截面研究.
- 认知功能使用由确认因素分析得出的复合分数进行评估.
- 在中位线上二分化的带-股骨脉冲波速率 (cfPWV).
- 使用单分子阵列 (Simoa) 技术量化血NfL水平.
主要成果:
- 较高的NfL水平与所有认知领域的表现较差相关.
- 较高的cfPWV与减少的情节性记忆,工作记忆和处理速度有关.
- 在情节性和工作记忆方面观察到NfL和cfPWV之间的显著相互作用,表明更高的cfPWV放大了NfL对这些认知领域的负面影响.
结论:
- 增加的动脉硬性显著放大了NfL相关的轴突退化和认知衰退之间的有害关联.
- 研究结果强调了血管衰老 (cfPWV) 和神经退行性标志物 (NfL) 在预测认知功能方面之间的协同作用.
- 单独评估NfL或cfPWV可能会低估它们对与年龄相关的认知障碍的综合影响.
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