对CPNE1的多omics解剖揭示了其在肝癌中的预后价值和免疫调节功能
Liu Liu1,2, He Hong3, Weiwei Zhang1
1Wannan Medical College, Wuhu, 241000, Anhui, China.
Discover oncology
|August 8, 2025
概括
肝细胞癌 (HCC) 中的Copine 1 (CPNE1) 含量升高,与预后不佳相关,并影响瘤免疫微环境. CPNE1可以作为HCC进展的生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肝细胞癌 (HCC) 呈现出高恶性瘤和不利的预后,尽管最近的治疗进展.
- 科平1 (CPNE1) 在HCC发育中的作用及其分子机制在很大程度上仍未被阐明.
- CPNE1是一种依赖的脂结合蛋白,与各种癌症类型有关.
研究的目的:
- 阐明CPNE1在肝细胞癌 (HCC) 中的作用.
- 调查CPNE1表达和HCC中的瘤免疫微环境之间的关系.
- 确定与HCC中CPNE1相关的潜在调节途径和生物标志物.
主要方法:
- 使用TCGA数据对CPNE1表达和预后进行全癌症分析.
- 生物信息分析包括表达,相关性,生存和ceRNA网络预测.
- 功能丰富分析,单细胞RNA测序和空间转录组学,以评估CPNE1在肝癌组织和免疫细胞中的作用.
主要成果:
- 在HCC组织中,CPNE1的表达显著上调,并与患者预后较差有关.
- 确定了SNHG6/hsa-miR-101-3p轴作为HCC中CPNE1的关键调节途径.
- 恶性肝细胞和免疫细胞 (特别是NK细胞) 中CPNE1的含量升高,可能通过MIF和PPIA-BSG通路调节肝癌免疫微环境.
结论:
- CPNE1与HCC的进展有关,并与预后不佳有关.
- 对于HCC,SNHG6/hsa-miR-101-3p/CPNE1监管轴被提议用于HCC.
- CPNE1显示出作为预测HCC患者预后不佳的生物标志物的潜力,并影响免疫微环境.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...