Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

Diels–Alder Reaction Forming Cyclic Products: Stereochemistry

The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement01:21

[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

The Cope rearrangement is classified as a [3,3] sigmatropic shift in 1,5-dienes, leading to a more stable, isomeric 1,5-diene. The reaction involves a concerted movement of six electrons, four from two π bonds and two from a σ bond, via an energetically favorable chair-like transition state.
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
Statically Indeterminate Problem Solving01:16

Statically Indeterminate Problem Solving

Statically indeterminate problems are those where statics alone can not determine the internal forces or reactions. Consider a structure comprising two cylindrical rods made of steel and brass. These rods are joined at point B and restrained by rigid supports at points A and C. Now, the reactions at points A and C and the deflection at point B are to be determined. This rod structure is classified as statically indeterminate as the structure has more supports than are necessary for maintaining...
Block Diagram Reduction01:22

Block Diagram Reduction

The process of deriving the transfer function of a control system often involves reducing its block diagram to a single block. This simplification can be achieved through a series of strategic operations, including relocating branch points and comparators. These operations preserve the overall function of the system while allowing for easier manipulation and combination of blocks.
The first step in this process is the identification and relocation of a branch point. A branch point, where a...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same author

Excited-state palladium-catalyzed defluorinative arylation of polyfluoroarenes.

Chemical communications (Cambridge, England)·2026
Same author

Pulsed electrolysis enables unexpected lactonization of bicyclobutane carboxylic acids.

Chemical science·2026
Same author

Photoinduced Palladium-Catalyzed Site-Selective Meta-Alkylation of Pyridines.

Angewandte Chemie (International ed. in English)·2026
Same author

INDIGENA: inductive prediction of disease-gene associations using phenotype ontologies.

Bioinformatics (Oxford, England)·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026
Same journal

Computational design of low-volatility lubricants for space using interpretable machine learning.

Journal of cheminformatics·2026
Same journal

OpenStats: how to combine statistics and research data management (RDM) to leverage efficient scientific data analysis by guided statistics.

Journal of cheminformatics·2026
Same journal

Unified heterogeneity-aware benchmark of drug synergy prediction: a cross-study analysis of traditional machine learning and graph deep learning models.

Journal of cheminformatics·2026
Same journal

Count your bits: fingerprint benchmarking to assess broad chemical space representation.

Journal of cheminformatics·2026
Same journal

Sampling out-of-distribution chemical spaces via Bayesian flow.

Journal of cheminformatics·2026
Same journal

Hold on tight: the kinetic profiling of opioid receptor ligands using the CORAL-MD.

Journal of cheminformatics·2026
查看所有相关文章

相关实验视频

Updated: May 10, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.2K

纳米设计师:解决复杂的CDR相互依赖性,通过代的改进.

Melissa Maria Rios Zertuche1, Şenay Kafkas2, Dominik Renn3

  • 1Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Saudi Arabia.

Journal of cheminformatics
|August 8, 2025
PubMed
概括
此摘要是机器生成的。

纳米设计师是一个新的AI工具,通过整合结构预测,对接和CDR生成来增强纳米体的新设计. 这种方法显著提高了创建功能单域抗体的成功率.

关键词:
抗体的设计设计.期望最大化 期望最大化生成性AI是一种人工智能.纳米体设计设计

更多相关视频

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.6K
Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles "Nanoblades"
09:23

Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles "Nanoblades"

Published on: March 31, 2021

5.1K

相关实验视频

Last Updated: May 10, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.2K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.6K
Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles "Nanoblades"
09:23

Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles "Nanoblades"

Published on: March 31, 2021

5.1K

科学领域:

  • 生物技术是生物技术.
  • 免疫学 免疫学 免疫学
  • 人工智能的人工智能

背景情况:

  • 卡梅利德重链仅抗体,也称为纳米体,是具有抗原结合能力的单域抗体.
  • 现有的抗体设计模型没有针对纳米体进行优化,通常需要劳动密集型实验结构.

研究的目的:

  • 介绍NanoDesigner,一种基于人工智能的生成工具,用于设计和优化纳米体.
  • 为了应对新的纳米体设计中的挑战,特别是对接和互补性确定区域 (CDR) 生成之间的相互依赖.

主要方法:

  • 纳米设计师采用一个代框架,利用一个预期最大化 (EM) 算法.
  • 该工具集成了结构预测,抗原-抗体对接,CDR生成和侧链包装.
  • 它通过不断改进来解决对接精度和CDR符合性的相互依赖.

主要成果:

  • 纳米设计师的成功率大约是新的纳米体设计的两倍.
  • 由人工智能驱动的代方法有效地完善了对接和CDR生成过程.
  • 这导致了更高效和成功的纳米体创造.

结论:

  • 纳米设计师在计算纳米体设计方面取得了重大进展.
  • 该工具通过整合多个设计阶段来克服以前模型的局限性.
  • 它为产生新型纳米体提供了更有效和更成功的方法.