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在类风湿性关节炎中,GM-CSF强化了巨细胞,使其从它们循环中的单细胞前体中保留炎症特征

Jianing Chen1, Minghua Zhan2,3, Yanling Zhao1

  • 1Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Journal of translational medicine
|August 8, 2025
PubMed
概括

颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 维持类风湿性关节炎 (RA) 单细胞衍生的巨细胞的亲炎状态,通过CCL22驱动T细胞反应. 这突出了关键的RA途径和潜在的治疗点.

关键词:
CCL2222 这是一本书.转基因-CSF分化的巨细胞.与M-CSF分化的巨细胞.在M1/M2中,它是M1/M2.类风湿性关节炎 类风湿性关节炎 类风湿性关节炎

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