在有或没有社区获得性肺炎的儿童中检测尿道肺炎球菌血清型
Lilliam Ambroggio1,2, Lindsay R Grant3, Jillian M Cotter4
1Section of Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA. Lilliam.Ambroggio@cuanschutz.edu.
BMC infectious diseases
|August 8, 2025
概括
尿抗原检测 (UAD) 试验对儿童肺炎球菌血清型监测有希望. 虽然UAD识别的血清型不同于鼻,但它可以帮助监测社区获得性肺炎 (CAP) 中的血清型分布.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 诊断试验开发 诊断试验开发
背景情况:
- 基于培养的Streptococcus pneumoniae的鉴定存在诊断方面的挑战.
- 尿抗原检测 (UAD) 试验为识别肺炎球菌血清型提供了一个潜在的解决方案.
- 评估新的UAD测定对于改善诊断能力至关重要.
研究的目的:
- 评估Pfizer的UAD1和UAD2测定对肺炎球菌血清型监测的有用性.
- 调查UAD在诊断儿童社区获得性肺炎 (CAP) 和上呼吸道感染 (URI) 中的作用.
- 通过UAD识别的肺炎球菌血清类型与通过鼻检测的血清类型进行比较.
主要方法:
- 3个月至5岁的患有呼吸道症状 (CAP或URI) 的儿童和健康的对照人被纳入.
- 用PCR分析鼻子拭子以检测肺炎链球菌使用PCR.
- 使用UAD测定用于检测尿样中的肺炎球菌血清型.
- 描述性统计数据被用来比较跨组的发现.
主要成果:
- 肺炎球菌鼻拭子阳性在CAP中为23%,在URI中为17%,在对照中为3%.
- 在13%的CAP病例和5%的URI病例中,UAD发现了肺炎球菌血清型.
- 尿液中最常见的血清型是19F,22F和9N,不同于鼻的发现 (3,15B/C,19F,35B).
- 鼻和UAD血清型之间的一致性很低 (3.7%在CAP,1.5%在URI).
结论:
- 在儿童呼吸道感染中,UAD测定显示了区分肺炎球菌血清型的潜力.
- 鼻腔和尿液血清型之间的差异表明UAD阳性不仅仅是由于运输.
- 瑞公司的UAD测定可能对人口层面监测CAP儿童肺炎球菌血清型分布有价值.
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