在尼泊尔波克哈拉新生儿重症监护病房出现抗生素耐药性模式
Ramchandra Bastola1, Shree Krishna Shrestha1, Rajan Paudel1
1Department of Pediatrics, PoAHS, Pokhara, Nepal.
Journal of Nepal Health Research Council
|August 8, 2025
概括
尼泊尔的新生儿败血症显示出高抗微生物耐药性,特别是像Pseudomonas和Acinetobacter这样的グラム阴性细菌. 这需要谨慎的抗生素处方,以对抗新生儿重症监护室的抗药性.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 新生儿护理 新生儿护理
背景情况:
- 新生儿败血症在尼泊尔是一个重大挑战,因为抗菌素耐药性不断升级.
- 了解局部耐药性模式对于有效的治疗策略至关重要.
研究的目的:
- 确定接受新生儿重症监护室 (NICU) 的新生儿培养证明感染的抗生素耐药性模式.
主要方法:
- 在波克哈拉卫生科学学院的NICU进行了一年的前性观察研究.
- 收集了新生儿的人口统计,临床和微生物学数据,这些数据具有阳性培养 (血液,脑脊液,内管,).
- 对所有已识别的分离物进行分析的抗微生物敏感性测试 (AST) 结果.
主要成果:
- 在1327名新生儿中,51名 (3.8%) 患有培养阳性感染.
- 格拉姆阴性细菌 (68.6%) 占主导地位,包括 Pseudomonas (23.5%) 和 Acinetobacter (17.6%).
- 观察到高耐药率:第三代素 (75%),氨基糖化物 (87%),诺基诺 (61%),青素 (59.3%),以及百分之百的耐卡巴胺在格拉姆阴性分离物中.
结论:
- 在尼泊尔的新生儿败血症中,格拉姆阴性病原体存在显著的抗菌耐药性,即使对保留的抗生素.
- 在NICU中迫切需要合理的抗生素处方和抗菌药物管理计划.
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