母亲的免疫激活和抗生素会影响后代的神经发育,行为和微生物群
Clara Deady1,2, Jamie FitzGerald3, Nirit Kara1,2
1Department of Anatomy & Neuroscience, University College Cork, Ireland.
Brain, behavior, & immunity - health
|August 8, 2025
概括
孕妇的炎症和在怀孕期间肠道微生物群的破坏会影响后代的神经发育. 这项研究表明,产前炎症会加剧行为和大脑的变化,而微生物组的改变会影响后代的肠道细菌多样性.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 微生物组研究 微生物组研究
背景情况:
- 孕期孕产妇的炎症和肠道微生物组的改变与后代的神经发育障碍有关.
- 影响神经发育结果的孕产妇免疫激活 (MIA) 和孕产妇肠道微生物群之间的相互作用尚未研究.
研究的目的:
- 调查母体肠道微生物组的破坏是否会加剧系统性炎症对后代大脑发育,行为和长期微生物组组成的影响.
- 探索产前炎症和微生物组失调对神经发育轨迹的综合影响.
主要方法:
- 怀孕的Sprague Dawley大鼠分别接受了低剂量脂聚糖 (LPS) 和抗生素尾酒,以诱导全身炎症和肠道微生物组的破坏.
- 评估了胚胎发育,后代行为 (类似焦虑和重复行为),前额叶皮质5HT1a受体表达和微生物组合.
主要成果:
- 产前LPS暴露导致胚胎身体和胎盘体重减少,后代增加焦虑类和重复性行为,并在前额叶皮质中减少5HT1a受体表达.
- 仅仅暴露于抗生素并没有导致行为变化,但减少了后代微生物组的α-多样性和物种丰富性.
- 联合暴露表明对神经发育和微生物组参数的影响加剧.
结论:
- 产前暴露于炎症和肠道微生物群的破坏显著影响后代的神经发育和长期健康.
- 母亲的免疫激活和微生物群状态相互作用,影响后代的神经发育结果.
- 对益生菌等治疗干预措施的进一步研究是有必要的,以减轻这些不良的产前影响.
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