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膜巨细胞维持组织局部化,并在易斯肺癌重编程的肺微环境中获得增强的抗瘤活性
Mengfei Ren1,2, Jiaxiang Dou2, Qian Yue1,2
1School of Basic Medical Sciences, Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China.
Frontiers in immunology
|August 8, 2025
概括
膜巨细胞 (AMs) 在携带瘤的肺部仍然活跃在瘤外肺微环境 (ETLME). 这些AM表现出增强的抗瘤能力,在瘤病变之外保持其功能.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 膜巨细胞 (AMs) 在肺免疫中至关重要.
- 它们在肺癌发生中的作用已知,但它们在瘤携带的肺中的地位尚不清楚.
- 瘤微环境 (TME) 通常具有免疫抑制作用,影响免疫细胞.
研究的目的:
- 在瘤携带肺的瘤外肺微环境 (ETLME) 中描述AMs的表型和功能.
- 在这种独特的微环境中研究AMs的动态行为和抗瘤潜力.
主要方法:
- 使用了Orthotopic易斯肺癌 (LLC) 的小鼠模型.
- 对瘤微环境 (TME) 和瘤外肺微环境 (ETLME) 的分析.
- 对AMs的表型表征,包括基因表达,细胞表面标记物 (CD11b,Siglec-F) 和功能分析 (细胞,细胞).
主要成果:
- 瘤诱导了一种炎症性ETLME,与免疫抑制性TME不同.
- 瘤病变中没有AM,但在ETLME中存在和活跃.
- 在ETLME中,AMs表现出激活的表型,增加的增殖/死亡平衡,增强的细胞和细胞活性,并保留了代谢功能.
- 在LLC经验丰富的AM体现出增强的抗瘤能力.
结论:
- 膜巨细胞在炎症ETLME中保持其组织局部和功能完整性.
- 在ETLME中的AMs具有表型激活,并具有增强的抗瘤能力.
- 这些发现突出了不同肺区在癌症发生过程中调节免疫细胞功能的不同作用.
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