脏手术后局部复发的光与影:什么时候,为什么以及如何管理
Luca Di Gianfrancesco1, Alessandro Crestani2, Antonio Amodeo1
1Department of Oncological Urology, Veneto Institute of Oncology (IOV), Padua, Italy.
Frontiers in urology
|August 8, 2025
概括
部分切除术 (PN) 后细胞癌的局部复发 (LR) 是一个临床挑战. 积极的外科边缘是关键的风险因素,需要定制的管理策略,以获得最佳的患者结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 局部复发 (LR) 对于因细胞癌 (RCC) 接受部分切除术 (PN) 的患者来说是一个重大问题.
- 了解LR后PN的风险因素和最佳管理策略对于改善患者结果至关重要.
研究的目的:
- 审查细胞癌 (RCC) 部分切除术 (PN) 后局部复发 (LR) 的文献.
- 为了确定与PN之后的LR相关的相对风险因素.
- 探索LR的最佳临床管理策略.
主要方法:
- 在主要的文献数据库中进行了全面的文献搜索.
- 该审查侧重于部分切除术 (PN) 后的局部复发 (LR) 率.
- 其次性结局包括积极的外科边缘 (PSM),检分数,病态阶段和生存率.
主要成果:
- 在PN后的LR率在文献中显示出显著的异质性.
- 积极的外科手术边缘 (PSM) 被确定为LR的重要风险因素.
- 其他确定的风险因素包括病态阶段,检分数和组织学变异.
结论:
- 部分切除术 (PN) 后的局部复发 (LR) 是一个相当大的临床挑战.
- 多学科评估和共享决策对于管理LR至关重要.
- 根据已确定的风险因素定制管理策略对于优化患者的治疗结果至关重要.
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