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ERCC2 Lys751Gln,Asp312Asn和Arg156Arg多态性与妇科癌症易感性之间的关联:一个元分析

Fen Chen¹, Jiayang Yu¹, Chun-Guang Wang¹

¹Department of Oncology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in oncology

|August 8, 2025

概括

切割修复交叉补充组2 (ERCC2) Lys751Gln多态性增加了妇科瘤风险,特别是卵巢癌. 其他ERCC2多态没有显示增加风险,Asp312Asn可能对宫癌有保护作用.

科学领域:

遗传学和基因组学遗传学和基因组学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

妇科瘤,包括宫癌,子宫内膜癌和卵巢癌,对妇女的健康构成重大威胁.
切割修复交叉补充组2 (ERCC2) 对于DNA修复至关重要,其多态性可能会影响癌症易感性.
之前对ERCC2多态性和妇科瘤风险的研究已经产生了不一致的结果.

研究的目的:

进行元分析,精确估计ERCC2多态 (Lys751Gln,Asp312Asn,Arg156Arg) 与妇科瘤风险之间的关联.
澄清现有文献中关于ERCC2基因变异及其在妇科癌症发生中的作用的相互矛盾的发现.

主要方法:

在主要数据库 (PubMed,Cochrane Library,Embase,Web of Science) 中对病例控制研究进行系统的文献搜索,截至2024年10月.
对19项研究 (9433例,13144例对照) 的元分析,使用Stata 17软件计算赔率比率 (OR) 和95%置信区间 (CI).
根据癌症类型,种族和研究设计进行了子组分析.

主要成果:

ERCC2 Lys751Gln 多态性与妇科瘤的风险增加有关 (OR 1.33,95% CI 1.06-1.66).
具体来说,Lys751Gln增加了卵巢癌的风险 (OR 1.39,95% CI 1.04-1.86),但不是宫癌或子宫内膜癌.
在一个衰退型模型中,ERCC2 Asp312Asn多态性没有显示增加的风险和对宫癌的保护作用 (OR0.53,95% CI 0.34-0.83). Arg156Arg多态性与瘤易感性没有关联.

结论:

ERCC2的Lys751Gln多态性是妇科瘤,特别是卵巢癌的危险因素.
ERCC2 Asp312Asn和Arg156Arg多态性与增加妇科瘤风险无关.
Asp312Asn的多态性可能会提供对宫癌的保护,这需要进一步研究.

关键词:

在ERCC2中,ERCC2是ERCC2的第一个成员.宫癌:子宫癌是一种癌症.这是子宫内膜癌的癌症.妇科新生病的发生.这是一个元分析.卵巢癌是发生在卵巢的癌症.多形态主义的多态主义.

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