胡卜素和糖尿病病之间的关系:来自NHANESES的见解
Lei Wang1, Tianpu Feng1, Ye Tan2
1Department of Clinical Laboratory, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, China.
Frontiers in nutrition
|August 8, 2025
概括
饮食中的胡卜素显示出与糖尿病病 (DN) 有复杂的联系. 在最佳摄入量下,α-胡卜素可能会保护,而β-胡卜素对男性有益,而烯可能会增加黑人群体的风险.
科学领域:
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 糖尿病病 (DN) 是糖尿病的一个主要并发症,对全球健康负担作出了重大贡献.
- 饮食中的胡卜素在DN的发展和进展中的作用尚不清楚.
- 了解这些关联可以为DN的预防策略提供信息.
研究的目的:
- 调查六种特定的胡卜素亚型的摄入量与糖尿病病 (DN) 风险之间的关系.
- 探索卡洛类药物摄入对DN风险的潜在性别和种族特异性影响.
- 为了确定最佳的食类胡卜素摄入水平,以预防DN.
主要方法:
- 国家健康和营养检查调查 (NHANES) 2007-2018年数据的横截面分析.
- 包括13,271名2型糖尿病 (T2DM) 和DN诊断记录的参与者.
- 权重多变量后勤回归模型被用来评估类胡卜素摄入量 (α-胡卜素,β-胡卜素,β-加密素,甘,黄素,紫素) 和DN之间的关联,并对共变量和本杰明尼-霍赫伯格校正进行调整.
主要成果:
- 在胡卜素摄入量和DN风险之间观察到非线性关联,性别和种族差异很大.
- 低α-胡卜素摄入量与75%的DN风险降低有关 (OR=0.25),而高摄入量显示出矛盾的增加 (OR=2.24).
- 摄入β-胡卜素显著降低了男性的DN风险 (OR=0.57),而烯摄入与非西班牙裔黑人个体 (OR=4.99) 的风险增加五倍有关.
结论:
- 饮食中的胡卜素摄入量表现出复杂的,非线性关联与DN风险,受性别和种族的影响.
- 特定的胡卜素的最佳摄入水平,如α-胡卜素,可能对预防DN至关重要.
- 个性化营养策略考虑营养值,性别和种族是建议管理DN的.
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