Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

szKendall: spatial-structural-zero-aware dissimilarity measures for subtype discovery using single cell Hi-C data.

Nature communications·2026
Same author

Can random walking on a Hi-C contact matrix lead to data quality improvement? An assessment.

PloS one·2025
Same author

Can Random Walking on a Hi-C Contact Matrix Lead to Data Quality Improvement? An Assessment.

bioRxiv : the preprint server for biology·2025
Same author

Amprenavir Mitigates Pepsin-Induced Transcriptomic Changes in Normal and Precancerous Esophageal Cells.

International journal of molecular sciences·2025
Same author

Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer.

Nature communications·2025
Same author

Integrative analysis identifies the atypical repressor E2F8 as a targetable transcriptional activator driving lethal prostate cancer.

Oncogene·2024

相关实验视频

Updated: Jul 1, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

409.7K

用单细胞Hi-C数据发现亚型的新型空间结构零意识不相似度测量.

Yongqi Liu, Victor Jin, Shili Lin

    bioRxiv : the preprint server for biology
    |August 8, 2025
    PubMed
    概括

    一个新的度量,结构零感知肯德尔的 (szKendall),通过区分真正的结构零和序列放弃来改进单细胞Hi-C数据的分析. 这增强了对基因组组织中细胞对细胞的变异性的理解.

    科学领域:

    • 基因组学就是基因组学.
    • 计算生物学 计算生物学
    • 生物物理学的生物物理.

    背景情况:

    • 高通量单细胞Hi-C (scHi-C) 能够研究3D基因组组织的可变性.
    • scHi-C数据通常稀疏,这给分析带来了挑战.
    • 现有的方法难以区分结构零 (SZs) 和退出 (DOs).

    研究的目的:

    • 为scHi-C数据分析开发一种新的不相似度指标.
    • 为了解决当前处理数据稀疏性和零类型的方法的局限性.
    • 为了改善3D基因组结构中细胞对细胞的变异性.

    主要方法:

    • 介绍结构零意识的肯达尔的 (szKendall).
    • szKendall 结合了 2D 接触矩阵结构和共享 SZs.
    • 通过模拟和真实 scHi-C 数据集进行评估.

    主要成果:

    • szKendall有效地捕获scHi-C数据中的关键结构特征.
    • 这种新型指标在细胞聚类方面表现出了卓越的表现.
    • 区分SZ和DO对于准确的分析至关重要.

    更多相关视频

    Capturing Chromosome Conformation Across Length Scales
    10:15

    Capturing Chromosome Conformation Across Length Scales

    Published on: January 20, 2023

    3.6K
    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
    09:32

    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

    Published on: October 14, 2022

    3.7K

    相关实验视频

    Last Updated: Jul 1, 2026

    Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
    22:27

    Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

    Published on: May 6, 2010

    409.7K
    Capturing Chromosome Conformation Across Length Scales
    10:15

    Capturing Chromosome Conformation Across Length Scales

    Published on: January 20, 2023

    3.6K
    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
    09:32

    Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

    Published on: October 14, 2022

    3.7K

    结论:

    • szKendall提供了一种更准确的方法来处理scHi-C数据不相似性.
    • 这种方法推进了单细胞3D基因组学的分析.
    • 对于了解细胞特异性基因组组织来说,SZ意识指标至关重要.