在人类一生中绘制结构性大脑不对称的图表
Lena Dorfschmidt1,2,3, Simon White4,5, Margaret Gardner1,2,3
1Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.
这项研究创建了来自138,000多个人的大脑不对称成长图表,揭示了大脑横向化的寿命模式. 这些工具有助于量化个体大脑的不对称性,并识别神经系统疾病的差异.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑发育 人类大脑发育
- 神经成像是一种神经成像.
背景情况:
- 大脑的横向化是一个关键的组织原则.
- 了解大脑不对称性对于研究神经系统疾病至关重要.
- 对大脑不对称性的现有规范数据是有限的.
研究的目的:
- 为大脑不对称性制定一个全面的,寿命长的规范框架.
- 为神经成像表型提供半球特定的生长图表.
- 为了能够量化与典型的大脑不对称的个体偏差.
主要方法:
- 来自128项神经成像研究的综合数据 (177,701次扫描,138,231人).
- 包括从20个月经后周到102岁的个体.
- 开发了皮层和皮层下大脑结构的规范性生长图表.
主要成果:
- 在整个生命周期中识别出明显的不对称空间模式 (早期向左,晚期向右).
- 为计算不对称性百分比分数生成工具.
- 在自闭症谱系障碍,精神分裂症和阿尔茨海默病中展示了群体级别的不对称差异.
结论:
- 这一规范性框架有助于更好地理解大脑侧向化及其神经可塑性.
- 工具有助于量化个体不对称性和临床应用.
- 这种开放的资源支持基础和临床神经科学研究.
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